Scientific Foundations
Genetic Architecture
Curated GWAS, eQTL, and polygenic risk data organized by disease, gene, and tissue with transparent scoring rules and ancestry representation tracking.
Environmental Modifiers
Exposure characterization from air pollution to psychosocial stress, with dose-response patterns, sensitive windows, and population-level effect modification.
Gene–Environment Interaction
Tissue-resolved mechanistic hypotheses connecting statistical associations to biological pathways through curated mechanism briefs and network analysis.
Atlas at a Glance
Disease Modules
Each module maps genetic architecture, environmental drivers, and gene–environment interactions for a specific condition.
Alzheimer's Disease
Alzheimer's disease (AD) is the leading cause of dementia, characterized by progressive neurodegeneration, amyloid-beta ...
View Module →Asthma
Asthma is a heterogeneous chronic respiratory disease characterized by variable airflow obstruction, bronchial hyperresp...
View Module →Atopic Dermatitis
Atopic dermatitis (eczema) is a chronic inflammatory skin disease characterized by pruritus, erythema, and barrier dysfu...
View Module →Bipolar Disorder
Bipolar disorder is a mood disorder characterized by recurrent episodes of mania or hypomania and depression. Pathophysi...
View Module →Breast Cancer
Breast cancer is the most common malignancy in women globally, arising from ductal or lobular epithelium. Pathophysiolog...
View Module →Colorectal Cancer
Colorectal cancer (CRC) encompasses malignancies arising from the colon or rectum, with adenocarcinoma comprising the ma...
View Module →Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation, ...
View Module →Coronary Artery Disease
Coronary artery disease (CAD) is the leading cause of death globally, characterized by atherosclerosis—the progressive b...
View Module →Hypertension
Hypertension (essential arterial hypertension) is a chronic condition characterized by sustained elevation of blood pres...
View Module →Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) comprises Crohn disease and ulcerative colitis, chronic disorders of the gastrointestin...
View Module →Ischemic Stroke
Ischemic stroke results from occlusion of cerebral arteries, causing focal brain ischemia and infarction. Etiologic subt...
View Module →Lung Cancer
Lung cancer encompasses carcinomas of the lung, predominantly non-small cell lung cancer (NSCLC) and small cell lung can...
View Module →Explore Modules
Knowledge Graph
Interactive network of entity relationships with filters, side panels, and subgraph export.
Mechanism Briefs
In-depth mini-reviews explaining mechanistic hypotheses linking exposures to disease.
Community Module
County-level exposure and health burden overlays with interpretable model explanations.
Educational Passport
Generate a personalized educational summary PDF. Completely stateless — no data stored.
Methods & Ethics
Scoring rules, data sources, pipeline architecture, ethical framework, and model cards.
Updates
Versioned changelog and annual reports tracking atlas evolution over time.