Updates & Changelog
Versioned changelog and release notes. See annual reports for year-over-year summaries.
Releases (reverse chronological)
Mechanism Brief: Sleep/Circadian Disruption in Metabolic and Mental Health
Published mechanism brief on sleep deprivation and circadian gene disruption (CLOCK, PER2) in metabolic syndrome and depression.
Mechanism Brief: JAK-STAT/IL-23/Th17 in Psoriasis and IBD
Published mechanism brief on JAK-STAT pathway environmental triggers (tobacco, infection, diet) in psoriasis and inflammatory bowel disease.
Mechanism Brief: BDNF and Psychosocial Stress in Depression
Published mechanism brief on BDNF Val66Met variant and stress-mediated epigenetic repression in major depressive disorder.
Mechanism Brief: Leptin-Melanocortin Pathway in Obesity
Published mechanism brief on FTO/MC4R variants and diet-gene interaction in obesity through leptin signaling and energy homeostasis.
GENARCH – Launch
Platform launch with expanded research database: genes, pathways, diseases, and environmental exposures from peer-reviewed biomedical and genomic studies. Community and Knowledge Graph modules are live. Follow us @genarch_offcial on Instagram.
Mechanism Brief: PPARG and Diet Quality in Type 2 Diabetes
Published mechanism brief on PPARG Pro12Ala variant and dietary fat/fiber gene-environment interaction in type 2 diabetes risk.
Mechanism Brief: Oxidative Stress Response Genes in Air Pollution
Published mechanism brief on GSTP1 and SOD2 variants in oxidative stress response to PM2.5 exposure, linking to asthma and cardiovascular disease.
GENARCH v1.0 — Initial Atlas Release
Initial release of the GENARCH atlas with seed content focused on asthma, PM2.5 air pollution, IL33 genetics, NF-κB pathway, and the PM2.5–IL33–NF-κB mechanism brief. Includes knowledge graph linking disease, exposure, gene, pathway, and tissue entities. Community module provides placeholder for Loudoun County, Virginia.
Annual Reports
Coming soon!