GSTP1

HIGH

Glutathione S-transferase pi 1

Chromosome: 11q13.2

Gene Overview

GSTP1 encodes glutathione S-transferase pi 1, which conjugates glutathione to electrophilic compounds and reactive oxygen species, detoxifying oxidative stress. The Ile105Val (rs1695) polymorphism alters enzyme activity and has been widely studied in gene–environment interactions with air pollution, tobacco smoke, and other oxidative exposures. GSTP1 variants modify associations between PM2.5 and asthma, and smoking and lung function. Expression is high in lung, liver, and epithelial tissues.

Molecular Function

glutathione transferase activity
detoxification
oxidative stress response

Protein class: glutathione transferase

Regulatory Annotation

Promoter activity: Inducible by Nrf2 under oxidative stress.

eQTL tissues: lung, liver, airway epithelium

Tissue Expression Context

lungTPM range: 30-100GTEx vv8

liverTPM range: 50-150

Pathways

Linked Diseases & Exposures

Diseases

asthma— G×E, strength 0.75
lung-cancer— G×E, strength 0.65

Exposures

air-pollution— G×E, strength 0.85
tobacco— G×E, strength 0.8

Mechanistic Hypotheses

GSTP1 Val105 variant confers reduced detoxification capacity; under high PM2.5 or smoking, asthma and lung function associations are amplified.

Islam et al. EHP 2014; multiple G×E cohorts.

HIGH

Confidence Rating

Overall evidence confidence for this gene entry: HIGH

References

1.Islam T, et al. (2014). GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma. Environmental Health Perspectives. doi:10.1289/ehp.1307459
2.Romieu I, et al. (2006). Glutathione S-transferase genotypes and asthma. Thorax. doi:10.1136/thx.2005.052399